ABSTRACT
This article carried material about the results of the investigation of peripheral blood cellular immunity parameters in the COVID-19 patients with <= 30% lung damage hospitalizated in 2020 year. When infected with SARS-CoV-2 on the background of severe lymphopenia and neutrophilia were revealed the multidirectional changing in a cellular immunity parameters, the severity and dynamics of which can be determined by the initial type of immune system response.
ABSTRACT
Against the background of priority attention paid to the COVID-19 pandemic, there are also cases of community-acquired pneumonia of a different genesis. Identification of the features of lung lesions in such diseases is relevant during the spread of seasonal respiratory infections. The comparative study of the dynamics of hematological and hemostasiological parameters of blood in patients with pneumonia of various origins is of interest in terms of searching for predictors of the prognosis of the diseases development. Aim. To compare the features of clinical symptoms, hematological and hemostasiological parameters in patients with pneumonia caused by COVID-19 and in patients with community-acquired pneumonia. Materials and methods. During cross-sectional study two groups were formed: group 1 consisted of 92 patients diagnosed with moderate community-acquired pneumonia caused by COVID-19 infection;group 2 included 40 patients diagnosed with moderate community-acquired bilateral polysegmental pneumonia. Results. It was found that patients with COVID-19 had an older age (69 vs 39.3 years), a lower body temperature at admission (37.5 vs 38.85 °C), a lower percentage of reduced oxygen saturation (less than 89 % in 5.4 % of cases vs 10 % of cases). In most cases, the average values of some hematological parameters in patients with COVID-19 did not go beyond the reference range. Leukopenia (below 4 × 109 cells/l) and lymphopenia (below 1.1 × 109 cells/l) were observed in 26 % and 38 % of cases respectively;thrombocytopenia (less than 100 × 109 cells/l) - in 12.2 % of cases;hyperfibrinogenemia (more than 4 g/l) - in 65.3 % of cases. A direct correlation was found between platelet levels and leukocytes (R = 0.53;p < 0.001) and lymphocytes (R = 0.29;p = 0.06). Compared with the patients of the group 2, on average, patients with COVID-19 had significantly lower levels of leukocytes and lymphocytes (2.5 times each;p < 0.001) and an increased level of fibrinogen (by 45 %;p < 0.001). Conclusion. In patients with pneumonia caused by COVID-19, we revealed the particular features of clinical symptoms, hematological and hemostasiological blood parameters compared to community-acquired nonspecific pneumonia. © 2021 Acta Biomedica Scientifica. All rights reserved.